Nature Communications (Dec 2022)
DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal
- Paola Cattaneo,
- Michael G. B. Hayes,
- Nina Baumgarten,
- Dennis Hecker,
- Sofia Peruzzo,
- Galip S. Aslan,
- Paolo Kunderfranco,
- Veronica Larcher,
- Lunfeng Zhang,
- Riccardo Contu,
- Gregory Fonseca,
- Simone Spinozzi,
- Ju Chen,
- Gianluigi Condorelli,
- Stefanie Dimmeler,
- Marcel H. Schulz,
- Sven Heinz,
- Nuno Guimarães-Camboa,
- Sylvia M. Evans
Affiliations
- Paola Cattaneo
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Michael G. B. Hayes
- Department of Medicine, University of California San Diego
- Nina Baumgarten
- Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University
- Dennis Hecker
- Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University
- Sofia Peruzzo
- Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University
- Galip S. Aslan
- Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University
- Paolo Kunderfranco
- IRCCS Humanitas Research Hospital
- Veronica Larcher
- Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University
- Lunfeng Zhang
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Riccardo Contu
- Department of Medicine, University of California San Diego
- Gregory Fonseca
- Department of Medicine, Meakins-Christie Laboratories, McGill University
- Simone Spinozzi
- Department of Medicine, University of California San Diego
- Ju Chen
- Department of Medicine, University of California San Diego
- Gianluigi Condorelli
- Institute of Genetic and Biomedical Research (IRGB), Milan Unit, National Research Council of Italy
- Stefanie Dimmeler
- Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University
- Marcel H. Schulz
- Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University
- Sven Heinz
- Department of Medicine, University of California San Diego
- Nuno Guimarães-Camboa
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Sylvia M. Evans
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-022-35070-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
How and whether histone modifications regulate distinct gene networks remains insufficiently understood. Here Cattaneo et al show that DOT1L catalyzed H3K79me2 regulates fetal chamber-specific gene expression and neonatal cardiomyocyte cell cycle withdrawal to coordinate heart development.
