1012 Deep peripheral blood immunophenotyping identifies a subgroup of lupus nephritis patients characterized by high type 1 interferon signaling, persistent activated immune cells and poor renal response to standard of care at 1 year

• ,
• Richard Furie,
• Judith A James,
• Maria Dall’Era,
• Michelle A Petri,
• Chaim Putterman,
• Peter Izmirly,
• Jill P Buyon,
• Diane L Kamen,
• Betty Diamond,
• David Wofsy,
• Soumya Raychaudhuri,
• Jennifer Grossman,
• Fan Zhang,
• Jun Inamo,
• Nir Hacohen,
• Alice Horisberger,
• Kenneth C Kalunian,
• Michael B Brenner,
• Mariko Ishimori,
• David Hildeman,
• Robert Clancy,
• ANNE DAVIDSON,
• Matthias Kretzler,
• Michael Weisman,
• Celine C Berthier,
• Andrea Fava,
• Takanori Sasaki,
• Jennifer L Barnas,
• Jennifer H Anolik,
• Paul J Hoover,
• Deepak A Rao,
• Joshua Keegan,
• James A Lederer,
• Joel Guthridge,
• Michael Belmont,
• Arnon Arazi,
• William Apruzzese,
• Fernanda Payan-Schober,
• Jeffrey Hodgin,
• Thomas M Eisenhaure,
• Steve Woodle,
• Maureen A McMahon,
• Ekaterina Murzin,
• Katie Preisinger,
• Alec Griffith,
• Kaitlyn Howard,
• Tusharkanti Ghosh,
• Rebecca Beuschel,
• John Pulford,
• Brandon Hancock,
• Maria Gutierrez-Arcelus

Affiliations

Richard Furie

7Hofstra Northwell School of Medicine, New York, NY, United States of America

Judith A James

8 Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

Maria Dall’Era

14Ohio State University, Columbus OH, United States of America

Michelle A Petri

1Queen Elizabeth II Health Sciences Center and Dalhousie University, Rheumatology/Medicine, Halifax, Nova Scotia, Canada

Chaim Putterman

Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA

Peter Izmirly

2 Rheumatology, NYU Grossman School of Medicine, New York City, New York, USA

Jill P Buyon

2 Rheumatology, NYU Grossman School of Medicine, New York City, New York, USA

Diane L Kamen

1Queen Elizabeth II Health Sciences Center and Dalhousie University, Rheumatology/Medicine, Halifax, Nova Scotia, Canada

Betty Diamond

8The Feinstein Institute for Medical Research, Manhasset, United States of America

David Wofsy

7UCSF Medical Center, San Francisco, United States of America

Soumya Raychaudhuri

University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, Manchester, United Kingdom

Jennifer Grossman

13University of California, Los Angeles CA, United States of America

Fan Zhang

Department of Nephrology A, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China

Jun Inamo

Keio University School of Medicine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan

Nir Hacohen

3Harvard Medical School, Boston, United States of America

Alice Horisberger

Centre Hospitalier Universitaire Vaudois (CHUV), Division of Immunology and Allergology, Lausanne, Switzerland

Kenneth C Kalunian

1Queen Elizabeth II Health Sciences Center and Dalhousie University, Rheumatology/Medicine, Halifax, Nova Scotia, Canada

Michael B Brenner

4 Division of Rheumatology, Immunology, and Allergy, Brigham and Women`s Hospital, Boston, Massachusetts, USA

Mariko Ishimori

Department of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA

David Hildeman

10University of Cincinnati, Cincinnati, United States of America

Robert Clancy

1NYU Langone Health, USA

ANNE DAVIDSON

8The Feinstein Institute for Medical Research, Manhasset, United States of America

Matthias Kretzler

9University of Michigan, Ann Arbor, United States of America

Michael Weisman

21Cedars-Sinai Medical Center, Los Angeles, United States of America

Celine C Berthier

Internal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA

Andrea Fava

1Johns Hopkins University, Baltimore, United States of America

Takanori Sasaki

1Keio University School of Medicine, Department of Internal Medicine, Division of Rheumatology, Tokyo, Japan

Jennifer L Barnas

University of Rochester, Rochester, NY, USA

Jennifer H Anolik

University of Rochester, Rochester, NY, USA

Paul J Hoover

1Broad Institute of MIT and Harvard, Cambridge MA, USA

Deepak A Rao

1 Division of Rheumatology, Inflammation, and Immunity, Brigham and Women`s Hospital, Boston, Massachusetts, USA

Joshua Keegan

1Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

James A Lederer

8Alloplex Biotherapeutics Inc, Woburn, MA, USA

Joel Guthridge

1Oklahoma Medical Research Foundation, Arthritis and Clinical Immunology, Oklahoma City, United States of America

Michael Belmont

6Rheumatology, NYU Grossman School of Medicine, USA

Arnon Arazi

4Broad Institute, Cambridge, United States of America

William Apruzzese

9Division of Rheumatology, Immunology, Allergy, Department of Medicine, Brigham and Women’s Hospital, Boston, USA

Fernanda Payan-Schober

Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA

Jeffrey Hodgin

3Pathology, University of Michigan, USA

Thomas M Eisenhaure

3Broad Institute of MIT and Harvard, Cambridge, MA, USA

Steve Woodle

7University of Cincinnati College of Medicine, Cincinnati, OH, USA

Maureen A McMahon

14University of California Los Angeles, Los Angeles, CA, USA

Ekaterina Murzin

1Brigham and Women’s Hospital, Boston, MA, USA

Katie Preisinger

1NYU Grossman School of Medicine, USA

Alec Griffith

1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Kaitlyn Howard

1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Tusharkanti Ghosh

4School of Public Health, University of Colorado, Anschutz Medical Campus, CO, USA

Rebecca Beuschel

1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

John Pulford

1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Brandon Hancock

1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Maria Gutierrez-Arcelus

8Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA