Nature Communications (Feb 2020)
Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
- Antonia E. Schantl,
- Anja Verhulst,
- Ellen Neven,
- Geert J. Behets,
- Patrick C. D’Haese,
- Marc Maillard,
- David Mordasini,
- Olivier Phan,
- Michel Burnier,
- Dany Spaggiari,
- Laurent A. Decosterd,
- Mark G. MacAskill,
- Carlos J. Alcaide-Corral,
- Adriana A. S. Tavares,
- David E. Newby,
- Victoria C. Beindl,
- Roberto Maj,
- Anne Labarre,
- Chrismita Hegde,
- Bastien Castagner,
- Mattias E. Ivarsson,
- Jean-Christophe Leroux
Affiliations
- Antonia E. Schantl
- Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich
- Anja Verhulst
- Laboratory of Pathophysiology, University of Antwerp
- Ellen Neven
- Laboratory of Pathophysiology, University of Antwerp
- Geert J. Behets
- Laboratory of Pathophysiology, University of Antwerp
- Patrick C. D’Haese
- Laboratory of Pathophysiology, University of Antwerp
- Marc Maillard
- Service of Nephrology and Hypertension, Lausanne University Hospital
- David Mordasini
- Service of Nephrology and Hypertension, Lausanne University Hospital
- Olivier Phan
- Service of Nephrology and Hypertension, Lausanne University Hospital
- Michel Burnier
- Service of Nephrology and Hypertension, Lausanne University Hospital
- Dany Spaggiari
- Division of Clinical Pharmacology, Lausanne University Hospital
- Laurent A. Decosterd
- Division of Clinical Pharmacology, Lausanne University Hospital
- Mark G. MacAskill
- University-BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh
- Carlos J. Alcaide-Corral
- University-BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh
- Adriana A. S. Tavares
- University-BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh
- David E. Newby
- University-BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh
- Victoria C. Beindl
- Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich
- Roberto Maj
- Inositec Inc.
- Anne Labarre
- Department of Pharmacology & Therapeutics, McGill University
- Chrismita Hegde
- Department of Pharmacology & Therapeutics, McGill University
- Bastien Castagner
- Department of Pharmacology & Therapeutics, McGill University
- Mattias E. Ivarsson
- Inositec Inc.
- Jean-Christophe Leroux
- Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich
- DOI
- https://doi.org/10.1038/s41467-019-14091-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystallization and inhibits soft tissue calcification in vivo following subcutaneous injection.
