The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

Nicolai Franzmeier; Anna Rubinski; Julia Neitzel; Michael Ewers; The Alzheimer’s Disease Neuroimaging Initiative (ADNI)

doi:10.1038/s41467-019-09564-5

Nature Communications (Apr 2019)

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

Nicolai Franzmeier,
Anna Rubinski,
Julia Neitzel,
Michael Ewers,
The Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Affiliations

Nicolai Franzmeier: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Anna Rubinski: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Julia Neitzel: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Michael Ewers: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
The Alzheimer’s Disease Neuroimaging Initiative (ADNI)

DOI: https://doi.org/10.1038/s41467-019-09564-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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The BIN1 SNP rs744373 is associated with higher CSF tau and phosphorylated tau levels. Here the authors show, using PET imaging, that this SNP is associated with tau accumulation in the brain as well as impaired memory in older individuals without dementia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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