A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly

Quanxia Lyu; Shu Gong; Jarmon G. Lees; Jialiang Yin; Lim Wei Yap; Anne M. Kong; Qianqian Shi; Runfang Fu; Qiang Zhu; Ash Dyer; Jennifer M. Dyson; Shiang Y. Lim; Wenlong Cheng

doi:10.1038/s41467-022-34860-y

Nature Communications (Nov 2022)

A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly

Quanxia Lyu,
Shu Gong,
Jarmon G. Lees,
Jialiang Yin,
Lim Wei Yap,
Anne M. Kong,
Qianqian Shi,
Runfang Fu,
Qiang Zhu,
Ash Dyer,
Jennifer M. Dyson,
Shiang Y. Lim,
Wenlong Cheng

Affiliations

Quanxia Lyu: Department of Chemical & Biological Engineering, Monash University
Shu Gong: Department of Chemical & Biological Engineering, Monash University
Jarmon G. Lees: O’Brien Institute Department, St. Vincent’s Institute of Medical Research
Jialiang Yin: Department of Chemical & Biological Engineering, Monash University
Lim Wei Yap: Department of Chemical & Biological Engineering, Monash University
Anne M. Kong: O’Brien Institute Department, St. Vincent’s Institute of Medical Research
Qianqian Shi: Department of Chemical & Biological Engineering, Monash University
Runfang Fu: Department of Chemical & Biological Engineering, Monash University
Qiang Zhu: The Melbourne Centre for Nanofabrication
Ash Dyer: The Melbourne Centre for Nanofabrication
Jennifer M. Dyson: Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute
Shiang Y. Lim: O’Brien Institute Department, St. Vincent’s Institute of Medical Research
Wenlong Cheng: Department of Chemical & Biological Engineering, Monash University

DOI: https://doi.org/10.1038/s41467-022-34860-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

It is challenging to directly characterize mechanical properties of soft 3D cardiac organoids with current sensors. Here the authors report an electronic skin-based all-soft organoid-sensing system which can wirelessly monitor minute force profiles of cardiac organoids in real-time in-situ.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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