ANALYSIS OF COMPLEX CARRIER STATE OF GENETIC POLYMORPHISMS ASSOCIATED WITH VARIOUS ISCHEMIC STROKE TYPES

Abstract

Frequencies of genotypes and alleles for 26 polymorphic variants of23 genes were statistically analyzed in 330patients with Ischemic stroke and 200 healthy subjects, matched for age and gender (p > 0,05) after genetic analysis (PCR-Ehf andPCR-Rt). SELP-1087A (OR = 1,6), SELP-1087GA (OR = l,96),SELE-128Pro (OR=2,66),SELE-128SerPro (OR=3,92), ApoC3-3238G (OR = 1,63), ApoC3-3238CG (OR = 1,95) alleles and genotypes were revealed to be associated with the disease independently (p < 0,05). MDR-method showed 2-6 components combinations of genotypes associated with the (non) development of lacunar ischemic stroke (prediction complexes: SELE-128Ser/ProxNOS3-786C/C (OR = 1,6) and PAI-1675/5G/4GxNOS3-786T/T*NOSl-84G/AxVEGF-A-2578A/C (OR = 6,0); protection complex: SELE-128Ser/ SerxNOS3-786C/T, OR=0,09) and atherothrombotic ischemic stroke (prediction complexes: NOSl-84A/AxApoC3- 3238C/C (OR = 3,0) and SELE-128Ser/ProxFRb-455G/AxNOSl-84G/A (OR = 10,0); protection complex: NOS1-84G/ GxApoC3-3238C/C (OR = 0,31)).

Keywords

• lacunar ischemic stroke
• atherothrombotic ischemic stroke
• genetic polymorphism
• multigenic inheritance