Study progress of the correlation between peri⁃implantitis，IL⁃1β，TNF⁃α and NF⁃κB signal transduction

Abstract

Increasing numbers of edentulous patients and patients with dental defects are willing to accept implant restorations. However，the development of peri⁃implantitis is a major factor leading to implant failure. The worsening of peri⁃implantitis promotes the secretion of inflammatory cytokines such as IL⁃1β and TNF⁃α and the gene expression of RANKL，inhibits the gene expression of OPG，and increases osteoclast activity，which promotes bone absorption indi⁃ rectly and leads to a negative balance in bone metabolism. To gain knowledge about the relationship between peri⁃im⁃ plantitis and NF⁃κB signaling pathways，this article summarizes related reports about peri⁃implantitis and NF⁃ κB sig⁃ naling pathways，explores the regulatory mechanism by which peri⁃implantitis affects bone metabolism and NF⁃ κB sig⁃ naling，discusses the effect of immunological cytokines on NF⁃ κB signaling pathways when inflammation arises，and provides a theoretical foundation for peri⁃implantitis research and prevention.

Keywords

• Peri⁃implantitis，
• Interleukin⁃1β，
• Tumor necrosis factor⁃α，
• Receptor activator for nuclear factor⁃ κB ligand，
• Osteoprotegerin，
• Nuclear transcription factor kappaB signaling pathways，