mBio (Apr 2021)
NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target
- Samuel Fenn,
- Jean-Frédéric Dubern,
- Cristina Cigana,
- Maura De Simone,
- James Lazenby,
- Mario Juhas,
- Stephan Schwager,
- Irene Bianconi,
- Gerd Döring,
- Jonas Elmsley,
- Leo Eberl,
- Paul Williams,
- Alessandra Bragonzi,
- Miguel Cámara
Affiliations
- Samuel Fenn
- ORCiD
- National Biofilms Innovation Centre, Nottingham University Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
- Jean-Frédéric Dubern
- ORCiD
- National Biofilms Innovation Centre, Nottingham University Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
- Cristina Cigana
- ORCiD
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
- Maura De Simone
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
- James Lazenby
- National Biofilms Innovation Centre, Nottingham University Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
- Mario Juhas
- Department of Microbiology, Institute of Plant Biology, University of Zürich, Zürich, Switzerland
- Stephan Schwager
- Department of Microbiology, Institute of Plant Biology, University of Zürich, Zürich, Switzerland
- Irene Bianconi
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
- Gerd Döring
- Institute of Medical Microbiology and Hygiene, University of Tübingen, Tübingen, Germany
- Jonas Elmsley
- National Biofilms Innovation Centre, Nottingham University Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
- Leo Eberl
- ORCiD
- Department of Microbiology, Institute of Plant Biology, University of Zürich, Zürich, Switzerland
- Paul Williams
- ORCiD
- National Biofilms Innovation Centre, Nottingham University Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
- Alessandra Bragonzi
- ORCiD
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
- Miguel Cámara
- ORCiD
- National Biofilms Innovation Centre, Nottingham University Biodiscovery Institute, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
- DOI
- https://doi.org/10.1128/mBio.00207-21
- Journal volume & issue
-
Vol. 12,
no. 2
Abstract
The emergence of widespread antimicrobial resistance has led to the need for development of novel therapeutic interventions. Antivirulence strategies are an attractive alternative to classic antimicrobial therapy; however, they require identification of new specific targets which can be exploited in drug discovery programs.
