Nature Communications (Oct 2019)
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
- Sarah Gooding,
- Sam W. Z. Olechnowicz,
- Emma V. Morris,
- Andrew E. Armitage,
- Joao Arezes,
- Joe Frost,
- Emmanouela Repapi,
- James R. Edwards,
- Neil Ashley,
- Craig Waugh,
- Nicola Gray,
- Erik Martinez-Hackert,
- Pei Jin Lim,
- Sant-Rayn Pasricha,
- Helen Knowles,
- Adam J. Mead,
- Karthik Ramasamy,
- Hal Drakesmith,
- Claire M. Edwards
Affiliations
- Sarah Gooding
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Sam W. Z. Olechnowicz
- Oxford Centre for Translational Myeloma Research, University of Oxford
- Emma V. Morris
- Oxford Centre for Translational Myeloma Research, University of Oxford
- Andrew E. Armitage
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Joao Arezes
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Joe Frost
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Emmanouela Repapi
- MRC Weatherall Institute of Molecular Medicine, University of Oxford
- James R. Edwards
- Oxford Centre for Translational Myeloma Research, University of Oxford
- Neil Ashley
- MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Craig Waugh
- MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Nicola Gray
- MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Erik Martinez-Hackert
- Department of Biochemistry and Molecular Biology, Michigan State University
- Pei Jin Lim
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Sant-Rayn Pasricha
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Helen Knowles
- Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford
- Adam J. Mead
- Oxford University Hospitals NHS Trust
- Karthik Ramasamy
- Oxford University Hospitals NHS Trust
- Hal Drakesmith
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Claire M. Edwards
- NIHR Oxford Biomedical Research Centre Blood Theme, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-019-12296-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease
