Coated Wire and Multiwalled Carbon Nanotube Composite Coated Wire Sensors for Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations.

Abstract

fabrication and performance characteristics of novel potentiometric sensors for the determination of chlorpromazine hydrochloride are described. The proposed sensors include a coated copper wire sensor and a multiwalled carbon nanotube (MWCNT) composite coated copper wire sensor. The sensors are based on the chlorpromazine-phosphotungstate ion associate as electroactive material. The developed sensors exhibited near nernstian slopes of 53.69 and 57.31 mV concentration decade-1 at 25 ◦C, in the concentration range 5.0 x 10-5 – 1.0 x 10-2 mol L-1 chlorpromazine hydrochloride with limits of detection of 4.8 x 10-5 and 4.9 x 10-5 mol L-1 chlorpromazine hydrochloride for coated copper wire sensor and a (MWCNT) composite coated copper wire sensor, respectively. The proposed sensors exhibited good selectivity for chlorpromazine with respect to a large number of inorganic cations, amino acid and sugars. The developed sensor was successfully applied for the potentiometric determination of chlorpromazine hydrochloride in the pharmaceutical preparations and human urine samples.

Keywords

• chlorpromazine hydrochloride
• pharmaceutical preparation
• human urine
• coated wire sensor