Frontiers in Aging Neuroscience (Jan 2021)
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases
- Johannes Boltze,
- Jaroslaw A. Aronowski,
- Jerome Badaut,
- Marion S. Buckwalter,
- Mateo Caleo,
- Mateo Caleo,
- Michael Chopp,
- Michael Chopp,
- Kunjan R. Dave,
- Nadine Didwischus,
- Rick M. Dijkhuizen,
- Thorsten R. Doeppner,
- Jens P. Dreier,
- Jens P. Dreier,
- Jens P. Dreier,
- Jens P. Dreier,
- Karim Fouad,
- Mathias Gelderblom,
- Karen Gertz,
- Karen Gertz,
- Dominika Golubczyk,
- Barbara A. Gregson,
- Edith Hamel,
- Daniel F. Hanley,
- Wolfgang Härtig,
- Friedhelm C. Hummel,
- Friedhelm C. Hummel,
- Maulana Ikhsan,
- Maulana Ikhsan,
- Maulana Ikhsan,
- Miroslaw Janowski,
- Jukka Jolkkonen,
- Saravanan S. Karuppagounder,
- Saravanan S. Karuppagounder,
- Richard F. Keep,
- Inga K. Koerte,
- Inga K. Koerte,
- Zaal Kokaia,
- Peiying Li,
- Fudong Liu,
- Ignacio Lizasoain,
- Peter Ludewig,
- Gerlinde A. S. Metz,
- Axel Montagne,
- Andre Obenaus,
- Alex Palumbo,
- Alex Palumbo,
- Alex Palumbo,
- Monica Pearl,
- Miguel Perez-Pinzon,
- Anna M. Planas,
- Anna M. Planas,
- Nikolaus Plesnila,
- Nikolaus Plesnila,
- Nikolaus Plesnila,
- Ami P. Raval,
- Maria A. Rueger,
- Lauren H. Sansing,
- Farida Sohrabji,
- Charlotte J. Stagg,
- Charlotte J. Stagg,
- R. Anne Stetler,
- Ann M. Stowe,
- Dandan Sun,
- Akihiko Taguchi,
- Mickael Tanter,
- Sabine U. Vay,
- Raghu Vemuganti,
- Denis Vivien,
- Denis Vivien,
- Piotr Walczak,
- Jian Wang,
- Ye Xiong,
- Marietta Zille,
- Marietta Zille,
- Marietta Zille
Affiliations
- Johannes Boltze
- School of Life Sciences, University of Warwick, Warwick, United Kingdom
- Jaroslaw A. Aronowski
- Institute for Stroke and Cerebrovascular Diseases, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States
- Jerome Badaut
- NRS UMR 5287, INCIA, Brain Molecular Imaging Team, University of Bordeaux, Bordeaux cedex, France
- Marion S. Buckwalter
- Departments of Neurology and Neurological Sciences, and Neurosurgery, Wu Tsai Neurosciences Institute, Stanford School of Medicine, Stanford, CA, United States
- Mateo Caleo
- Neuroscience Institute, National Research Council, Pisa, Italy
- Mateo Caleo
- Department of Biomedical Sciences, University of Padua, Padua, Italy
- Michael Chopp
- Department of Neurology, Henry Ford Hospital, Detroit, MI, United States
- Michael Chopp
- Department of Physics, Oakland University, Rochester, MI, United States
- Kunjan R. Dave
- Peritz Scheinberg Cerebral Vascular Disease Research Laboratory, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States
- Nadine Didwischus
- School of Life Sciences, University of Warwick, Warwick, United Kingdom
- Rick M. Dijkhuizen
- 0Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands
- Thorsten R. Doeppner
- 1Department of Neurology, University Medical Center Göttingen, Göttingen, Germany
- Jens P. Dreier
- 2Department of Neurology, Center for Stroke Research Berlin, Charité—Universitätsmedizin Berlin, Berlin, Germany
- Jens P. Dreier
- 3Department of Experimental Neurology, Charité—Universitätsmedizin Berlin, Berlin, Germany
- Jens P. Dreier
- 4Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany
- Jens P. Dreier
- 5Einstein Center for Neurosciences Berlin, Berlin, Germany
- Karim Fouad
- 6Faculty of Rehabilitation Medicine and Institute for Neuroscience and Mental Health, University of Alberta, Edmonton, AB, Canada
- Mathias Gelderblom
- 7Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Karen Gertz
- 2Department of Neurology, Center for Stroke Research Berlin, Charité—Universitätsmedizin Berlin, Berlin, Germany
- Karen Gertz
- 8Berlin Institute of Health, Berlin, Germany
- Dominika Golubczyk
- 9Department of Neurosurgery, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland
- Barbara A. Gregson
- 0Neurosurgical Trials Group, Institute of Neuroscience, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
- Edith Hamel
- 1Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
- Daniel F. Hanley
- 2Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, United States
- Wolfgang Härtig
- 3Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
- Friedhelm C. Hummel
- 4Clinical Neuroengineering, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology Valais, Clinique Romande de Réadaptation, Sion, Switzerland
- Friedhelm C. Hummel
- 5Clinical Neuroscience, University of Geneva Medical School, Geneva, Switzerland
- Maulana Ikhsan
- 6Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
- Maulana Ikhsan
- 7Fraunhofer Research Institution for Marine Biotechnology and Cell Technology, Lübeck, Germany
- Maulana Ikhsan
- 8Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany
- Miroslaw Janowski
- 9Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States
- Jukka Jolkkonen
- 0Department of Neurology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
- Saravanan S. Karuppagounder
- 1Burke Neurological Institute, White Plains, NY, United States
- Saravanan S. Karuppagounder
- 2Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States
- Richard F. Keep
- 3Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States
- Inga K. Koerte
- 4Psychiatric Neuroimaging Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States
- Inga K. Koerte
- 5Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig Maximilians University, Munich, Germany
- Zaal Kokaia
- 6Lund Stem Cell Center, Lund University, Lund, Sweden
- Peiying Li
- 7Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
- Fudong Liu
- 8Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, United States
- Ignacio Lizasoain
- 9Unidad de Investigación Neurovascular, Departamento Farmacología y Toxicología, Facultad de Medicina, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense de Madrid, Madrid, Spain
- Peter Ludewig
- 7Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Gerlinde A. S. Metz
- 0Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
- Axel Montagne
- 1Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
- Andre Obenaus
- 2Department of Pediatrics, University of California, Irvine, Irvine, CA, United States
- Alex Palumbo
- 6Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
- Alex Palumbo
- 7Fraunhofer Research Institution for Marine Biotechnology and Cell Technology, Lübeck, Germany
- Alex Palumbo
- 8Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany
- Monica Pearl
- 3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Miguel Perez-Pinzon
- Peritz Scheinberg Cerebral Vascular Disease Research Laboratory, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States
- Anna M. Planas
- 4Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Àrea de Neurociències, Barcelona, Spain
- Anna M. Planas
- 5Department d’Isquèmia Cerebral I Neurodegeneració, Institut d’Investigacions Biomèdiques de Barcelona (IIBB), Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain
- Nikolaus Plesnila
- 6Institute for Stroke and Dementia Research (ISD), Munich University Hospital, Munich, Germany
- Nikolaus Plesnila
- 7Graduate School of Systemic Neurosciences (GSN), Munich University Hospital, Munich, Germany
- Nikolaus Plesnila
- 8Munich Cluster of Systems Neurology (Synergy), Munich, Germany
- Ami P. Raval
- Peritz Scheinberg Cerebral Vascular Disease Research Laboratory, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States
- Maria A. Rueger
- 9Faculty of Medicine and University Hospital, Department of Neurology, University of Cologne, Cologne, Germany
- Lauren H. Sansing
- 0Department of Neurology, Yale University School of Medicine, New Haven, CT, United States
- Farida Sohrabji
- 1Women’s Health in Neuroscience Program, Neuroscience and Experimental Therapeutics, Texas A&M College of Medicine, Bryan, TX, United States
- Charlotte J. Stagg
- 2Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom
- Charlotte J. Stagg
- 3MRC Brain Network Dynamics Unit, University of Oxford, Oxford, United Kingdom
- R. Anne Stetler
- 4Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA, United States
- Ann M. Stowe
- 5Department of Neurology and Neurotherapeutics, Peter O’Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, United States
- Dandan Sun
- 6Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, PA, United States
- Akihiko Taguchi
- 7Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan
- Mickael Tanter
- 8Institute of Physics for Medicine Paris, INSERM U1273, ESPCI Paris, CNRS FRE 2031, PSL University, Paris, France
- Sabine U. Vay
- 9Faculty of Medicine and University Hospital, Department of Neurology, University of Cologne, Cologne, Germany
- Raghu Vemuganti
- 9Department of Neurological Surgery, University of Wisconsin, Madison, WI, United States
- Denis Vivien
- 0UNICAEN, INSERM, INSERM UMR-S U1237, Physiopathology and Imaging for Neurological Disorders (PhIND), Normandy University, Caen, France
- Denis Vivien
- 1CHU Caen, Clinical Research Department, CHU de Caen Côte de Nacre, Caen, France
- Piotr Walczak
- 9Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States
- Jian Wang
- 2Department of Human Anatomy, College of Medical Sciences, Zhengzhou University, Zhengzhou, China
- Ye Xiong
- 3Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, United States
- Marietta Zille
- 6Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
- Marietta Zille
- 7Fraunhofer Research Institution for Marine Biotechnology and Cell Technology, Lübeck, Germany
- Marietta Zille
- 8Institute for Medical and Marine Biotechnology, University of Lübeck, Lübeck, Germany
- DOI
- https://doi.org/10.3389/fnagi.2021.623751
- Journal volume & issue
-
Vol. 13
Abstract
The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.
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