GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

Raha Pazoki; Evangelos Evangelou; David Mosen-Ansorena; Rui Climaco Pinto; Ibrahim Karaman; Paul Blakeley; Dipender Gill; Verena Zuber; Paul Elliott; Ioanna Tzoulaki; Abbas Dehghan

doi:10.1038/s41467-019-11451-y

Nature Communications (Aug 2019)

GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

Raha Pazoki,
Evangelos Evangelou,
David Mosen-Ansorena,
Rui Climaco Pinto,
Ibrahim Karaman,
Paul Blakeley,
Dipender Gill,
Verena Zuber,
Paul Elliott,
Ioanna Tzoulaki,
Abbas Dehghan

Affiliations

Raha Pazoki: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Evangelos Evangelou: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
David Mosen-Ansorena: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Rui Climaco Pinto: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Ibrahim Karaman: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Paul Blakeley: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Dipender Gill: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Verena Zuber: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Paul Elliott: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Ioanna Tzoulaki: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus
Abbas Dehghan: MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s campus

DOI: https://doi.org/10.1038/s41467-019-11451-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Levels of sodium and potassium in urine are associated with cardiovascular traits. Here, Pazoki et al. perform genome-wide association studies for urinary sodium and potassium secretion and identify 50 and 13 novel loci, respectively, some of which show a potential causal relationship with blood pressure based on MR analysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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