A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress

Wezley C. Griffin; David R. McKinzey; Kathleen N. Klinzing; Rithvik Baratam; Achini Eliyapura; Michael A. Trakselis

doi:10.1038/s41467-022-32583-8

Nature Communications (Aug 2022)

A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress

Wezley C. Griffin,
David R. McKinzey,
Kathleen N. Klinzing,
Rithvik Baratam,
Achini Eliyapura,
Michael A. Trakselis

Affiliations

Wezley C. Griffin: Department of Chemistry and Biochemistry, Baylor University
David R. McKinzey: Department of Chemistry and Biochemistry, Baylor University
Kathleen N. Klinzing: Department of Chemistry and Biochemistry, Baylor University
Rithvik Baratam: Department of Chemistry and Biochemistry, Baylor University
Achini Eliyapura: Department of Chemistry and Biochemistry, Baylor University
Michael A. Trakselis: Department of Chemistry and Biochemistry, Baylor University

DOI: https://doi.org/10.1038/s41467-022-32583-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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The MCM8/9 helicase has been implicated in DNA recombination processes with mutations in these genes causative for infertility and cancer. Here, the authors show that MCM8/9 aids normal fork progression and also stabilizes persistently stalled forks, acting upstream of RAD51 and BRCA1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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