PLoS ONE (Jan 2023)

Premature mortality and years of potential life lost from cardiovascular diseases: Protocol of a systematic review and meta-analysis.

  • Wan Shakira Rodzlan Hasani,
  • Nor Asiah Muhamad,
  • Nur Hasnah Maamor,
  • Tengku Muhammad Hanis,
  • Chen Xin Wee,
  • Muhammad Radzi Abu Hassan,
  • Zulkarnain Abdul Karim,
  • Kamarul Imran Musa

DOI
https://doi.org/10.1371/journal.pone.0284052
Journal volume & issue
Vol. 18, no. 5
p. e0284052

Abstract

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IntroductionDespite the burden of cardiovascular disease (CVD) continuing to increase globally, no comprehensive meta-analyses have been conducted quantifying premature CVD mortality. This paper reports the protocol for a systematic review and meta-analysis to derive updated estimates of premature CVD mortality.Methods and expected outputsThis review will include the studies that reported premature CVD mortality based on standard premature mortality indicators, including years of life lost (YLL), age standardized mortality rate (ASMR) or standardised mortality ratio (SMR). PUBMED, Scopus, Web of Science (WoS), CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) will be used as the literature databases. The study selection as well as the evaluation of the quality of the included articles will be done independently by two reviewers. Pooled estimates of YLL, ASMR, and SMR will be computed by applying random-effects meta-analysis. Heterogeneity among selected studies will be assessed using the I2 statistic and Q statistic with associated p-values. A funnel plot analysis and Egger's test will be conducted to assess the potential impact of publication bias. Depending on data availability, we propose to conduct subgroup analyses by sex, geographic location, main CVD types, and study time. Reporting of our findings will follow the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.ConclusionOur meta-analysis will provide a comprehensive synthesis of the available evidence on premature CVD mortality, which is a major public health concern worldwide. The results of this meta-analysis will have important implications for clinical practice and public health policy, providing insights into strategies to prevent and manage premature CVD mortality.Trial registrationSystematic review registration: PROSPERO CRD42021288415. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288415.