Cu-catalyzed asymmetric addition of alcohols to β,γ-alkynyl-α-imino esters for the construction of linear chiral N,O-ketals

Abstract

N,O-acetals are part of many synthetic intermediates and important skeletons of numerous natural products and pharmaceutical drugs. Here the authors show a Cu-catalyzed asymmetric addition of alcohols to β,γ-alkynyl-α-imino esters, providing the corresponding linear chiral N,O-ketals with up to 96% ee.