Construction and function analysis of the LncRNA-miRNA-mRNA competing endogenous RNA network in autoimmune hepatitis

Abstract

Research Highlights It was the first time to explore the disorder of ceRNA network involved in the pathogenesis of AIH. The co-expression relationship between the differentially expressed lncRNAs, miRNAs and mRNAs were predicted. The potential biological features and enriched pathways for mRNAs constructed in the ceRNA network, which may be closely associated with the occurrence of AIH, were disclosed. Several latent targets, located in the center of the constructed ceRNA network, were provided to investigate the development of this disorder in depth.

Keywords

• Autoimmune hepatitis
• Concanavalin A
• ceRNA
• lncRNA
• miRNA
• microarray