Nature Communications (May 2022)
RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
- Adam E. Hall,
- Sebastian Öther-Gee Pohl,
- Patrizia Cammareri,
- Stuart Aitken,
- Nicholas T. Younger,
- Michela Raponi,
- Caroline V. Billard,
- Alfonso Bolado Carrancio,
- Aslihan Bastem,
- Paz Freile,
- Fiona Haward,
- Ian R. Adams,
- Javier F. Caceres,
- Paula Preyzner,
- Alex von Kriegsheim,
- Malcolm G. Dunlop,
- Farhat V. Din,
- Kevin B. Myant
Affiliations
- Adam E. Hall
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Sebastian Öther-Gee Pohl
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Patrizia Cammareri
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Stuart Aitken
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Nicholas T. Younger
- Centre for Inflammation Research, University of Edinburgh
- Michela Raponi
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Caroline V. Billard
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Alfonso Bolado Carrancio
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Aslihan Bastem
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Paz Freile
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Fiona Haward
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Ian R. Adams
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Javier F. Caceres
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Paula Preyzner
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Alex von Kriegsheim
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Malcolm G. Dunlop
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Farhat V. Din
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- Kevin B. Myant
- Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus
- DOI
- https://doi.org/10.1038/s41467-022-30489-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
The influence of mRNA splicing on colon cancer development and progression is unclear. In this study, the authors demonstrate that the SRSF1 splicing factor is essential to sustain the stem cell phenotype of WNT-activated colorectal cancers.
