Diagnostics (Nov 2024)

Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels

  • Ruxandra Maria Christodorescu,
  • Daniel Miron Brie,
  • Alina Diduța Brie,
  • Samuel Nistor,
  • Alexandru Tîrziu,
  • Angela Dragomir,
  • Cristian Mornoș,
  • Simona Drăgan,
  • Daniel Duda-Seiman,
  • Adina Pop-Moldovan,
  • Dan Dărăbanțiu

DOI
https://doi.org/10.3390/diagnostics14222507
Journal volume & issue
Vol. 14, no. 22
p. 2507

Abstract

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Background: NT-proBNP levels with a wide range at admission play both a diagnostic and a prognostic role in patients with HF. The differences regarding the clinical profiles and demography in decompensated HF patients according to NT-proBNP levels at admission are not clear. Methods: This study aimed to analyze and compare clinical profiles and demographics in patients hospitalized for decompensated heart failure according to levels of NT-proBNP at admission. The study included 302 patients hospitalized for decompensated HF who were divided into three groups based on admission NT-proBNP levels: group A (n = 46, with NT-proBNP level 10,000 pg/mL). Results: Patients hospitalized with decompensated HF and very high levels of NTproBNP, above 10,000 pg/mL at admission, are older, have a lower LVEF, higher NYHA class, more renal dysfunction, and longer hospital stay, resulting in a more severe clinical profile. Conclusions: The presence of very high levels of NT-proBNP may identify a category of patients with a more severe prognosis that requires more aggressive management and closer follow-up.

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