Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Cong-Lin Liu; Xian Zhang; Jing Liu; Yunzhe Wang; Galina K. Sukhova; Gregory R. Wojtkiewicz; Tianxiao Liu; Rui Tang; Samuel Achilefu; Matthias Nahrendorf; Peter Libby; Junli Guo; Jin-Ying Zhang; Guo-Ping Shi

doi:10.1038/s41467-019-11983-3

Nature Communications (Sep 2019)

Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Cong-Lin Liu,
Xian Zhang,
Jing Liu,
Yunzhe Wang,
Galina K. Sukhova,
Gregory R. Wojtkiewicz,
Tianxiao Liu,
Rui Tang,
Samuel Achilefu,
Matthias Nahrendorf,
Peter Libby,
Junli Guo,
Jin-Ying Zhang,
Guo-Ping Shi

Affiliations

Cong-Lin Liu: Department of Cardiology, Institute of Clinical Medicine, the First Affiliated Hospital of Zhengzhou University
Xian Zhang: Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Jing Liu: Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Yunzhe Wang: Department of Cardiology, Institute of Clinical Medicine, the First Affiliated Hospital of Zhengzhou University
Galina K. Sukhova: Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Gregory R. Wojtkiewicz: Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School
Tianxiao Liu: Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Rui Tang: Mallinckrodt Institute of Radiology, Washington University School of Medicine
Samuel Achilefu: Mallinckrodt Institute of Radiology, Washington University School of Medicine
Matthias Nahrendorf: Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School
Peter Libby: Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Junli Guo: Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Jin-Ying Zhang: Department of Cardiology, Institute of Clinical Medicine, the First Affiliated Hospital of Zhengzhou University
Guo-Ping Shi: Department of Cardiology, Institute of Clinical Medicine, the First Affiliated Hospital of Zhengzhou University

DOI: https://doi.org/10.1038/s41467-019-11983-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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