Influence of trached extubation time on the emergent agitation during the recovery of sevoflurane combined anesthesia in infants

Abstract

Objective To investigate the influence of trached extubation time on the emergent agitation during the recovery of sevoflurane combined anesthesia in infants. Methods Sevoflurane, propofol and remifentanil were com⁃ bined to maintain general anesthesia after intubation. The propofol infusion was stopped 10 minutes before the opera⁃ tion, and the remifentanil infusion was stopped 5 minutes before the end of the operation. The sevoflurane concentration was reduced to 1%, and the oxygen flow was adjusted to 6 L/min when the sevoflurane inhalation was stopped. Ninety infant patients with cleft palate were randomized into 3 groups (n＝30): 30 patients in group A were extubated within 5 minutes, 30 patients in group B were extubated between 5 and 10 minutes, and 30 patients in group C were extubated after 10 minutes. A postoperative agitation score was given after extubation and recorded away from the operating room.Propofol was administered when agitation occurred. The recovery time after the operation and time away from the operat⁃ ing room were recorded. Results The recovery times of group A, group B, and group C were 21.8 ± 2.5 minutes, 21.4 ± 2.1 minutes and 20.9 ± 1.3 minutes, respectively, although the differences were not significant (P > 0.05). The times away from the operating room of group A, group B, and group C were 8.1 ± 1.6 minutes, 5.2 ± 2.0 minutes and 2.1 ± 0.7 minutes, respectively, and the differences were statistically significant (P < 0.05). When endotracheal intubation was re⁃ moved, the incidence of agitation in group A (26/30) was higher than that in group B (16/30) and group C (5/30), and the differences were statistically significant (P < 0.05). The incidence of agitation in group B was also significantly dif⁃ ferent from that in group C (P < 0.05). Conclusion Propofol, which is used to control coughing and prolong the extuba⁃ tion time, can effectively prevent emergent agitation during the recovery period from sevoflurane⁃based anesthesia in in⁃ fants. The optimum time of extubation was 15 minutes.

Keywords

• General anesthesia，
• Optimum time point，
• Sevoflurane，
• Anesthesia recovery period，
• Agitation，
• Infant，