Communications Biology (Jun 2021)

Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line

  • Silke Pudewell,
  • Christoph Wittich,
  • Neda S. Kazemein Jasemi,
  • Farhad Bazgir,
  • Mohammad R. Ahmadian

DOI
https://doi.org/10.1038/s42003-021-02149-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 10

Abstract

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Pudewell et al. discuss and advance our understanding of accessory proteins, which are crucial for the RTK-RAS-MAPK signalling cascade. They consider the therapeutic potential of targeting such modulators as an alternative to targeting constituent components of the RTK-RAS-MAPK signalling cascade in the treatment of diseases such as cancer.