Anticancer acitivity of Schiff base ligand(E)-4-((5-chloro-2 hydroxybenzylidene) amino)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)- one and its Co(II), Cu(II) and Zn(II) metal complexes

Abstract

A series of transition metal complexes of Mn(II),Co(II), Ni(II), Cu(II), Zn(II) and VO(II) have been prepared by using the Schiff base ligand (L) derived from 4-aminoantipyrine and 5-chlorosalicylaldehyde. The structural properties of Schiff base ligand were characterized by mass, FT-IR, UV– –Vis, 1H-NMR spectroscopy, etc. Also, metal complexes were studied by P- -XRD, elemental analysis, thermogravimetric studies along with various biological activities. The micro analytical data revealed that, the metal complexes have 1:1 stoichiometry composition of M:L. Generally, it is observed that prepared metal complexes show better antifungal, antibacterial and anticancer activities than its Schiff base ligand.

Keywords

• schiff base ligand
• metal complexes
• 5-chlorosalicylaldehyde
• 4-aminoantipyrine