THE EFFECT OF HPMC AS A GEL BASE AND TWEEN 80 SPAN 80 COMBINATIONS AS EMULGATORS IN ACETOSAL TRANSDERMAL EMULGEL PREPARATIONS

Abstract

Acetosal or acetyl salicylic acid is a drug that has efficacy as ananalgesic, antipireic, and antiplatelet. Aacetosal undegoes cross-first metabolisism (first pass effect) causing low drug bioavailability. The smal lsolubility of acetosal will affect the rate of absorption which later affect the intensity of treatment, so transdermal delivery in emulgel dosage forms can be one of. In this study an experimental method was used by formulating an acetosal transdermal emulgel preparation, as a gel base HPMC was used at a concentration of 4%, 4.5%, 5% also variation of tween 80 concentration 6%, 5%, 4% and variation of Span 80 concentration 4%, 5%, 6% as an emulgator. Then a physical evaluation of the preparation was carried out which included organoleptic tests, pH tests, homogeneity tests, emulsion type tests, viscosity tests, spreadability tests and irritation tests. The results of the study showed that the formula 1 emulgel was bone white while formulas 2 and 3 were white, the pH of the preparation ranged from 4.83-5.57, the preparation was homogeneous with an O/A emulsion type, the viscosity value of the preparation ranged from 126.67-290 cPa. s, the dispersion value ranged from 5.20-6.30 and the preparation was not irritating.

Keywords

• HPMC
• Tween 80
• Span 80
• Emulgel transdermal
• Acetosal