Nature Communications (Nov 2017)

Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis

  • Manuel Hotz,
  • W. James Nelson

DOI
https://doi.org/10.1038/s41467-017-01536-x
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at the cell front during dynamic cell migration.