Nature Communications (Nov 2017)
Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
Abstract
Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at the cell front during dynamic cell migration.