Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

Evan Bardot; Damelys Calderon; Francis Santoriello; Songyan Han; Kakit Cheung; Bharati Jadhav; Ingo Burtscher; Stanley Artap; Rajan Jain; Jonathan Epstein; Heiko Lickert; Valerie Gouon-Evans; Andrew J. Sharp; Nicole C. Dubois

doi:10.1038/ncomms14428

Nature Communications (Feb 2017)

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

Evan Bardot,
Damelys Calderon,
Francis Santoriello,
Songyan Han,
Kakit Cheung,
Bharati Jadhav,
Ingo Burtscher,
Stanley Artap,
Rajan Jain,
Jonathan Epstein,
Heiko Lickert,
Valerie Gouon-Evans,
Andrew J. Sharp,
Nicole C. Dubois

Affiliations

Evan Bardot: Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Damelys Calderon: Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Francis Santoriello: Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Songyan Han: Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Kakit Cheung: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Bharati Jadhav: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Ingo Burtscher: Institute of Diabetes and Regeneration Research at the Helmholtz Zentrum München, German Center for Diabetes Research (DZD)
Stanley Artap: Departments of Cell and Developmental Biology and Medicine, Cardiovascular Institute, University of Pennsylvania
Rajan Jain: Departments of Cell and Developmental Biology and Medicine, Cardiovascular Institute, University of Pennsylvania
Jonathan Epstein: Departments of Cell and Developmental Biology and Medicine, Cardiovascular Institute, University of Pennsylvania
Heiko Lickert: Institute of Diabetes and Regeneration Research at the Helmholtz Zentrum München, German Center for Diabetes Research (DZD)
Valerie Gouon-Evans: Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Andrew J. Sharp: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Nicole C. Dubois: Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/ncomms14428
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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The progenitor populations that contribute to the key cardiac lineages in a chamber-specific manner are unknown. Here, the authors identifyFoxa2+ progenitor population, which is specified at gastrulation, as contributing primarily to cardiovascular cells of both ventricles and the epicardium in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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