Pharmacokinetics and bioavailability of difloxacin in camel

Abstract

The pharmacokinetic profile of difloxacin was investigated in camels after single intravenous and intramuscular administration of 5 mg kg-1 b.wt. After i. v. injection, serum concentration time curve was best described as two compartment open model. The distribution and elimination half lives (t0.5 (') and t0.5())) were 0.513± 0.01 h and 6.3±0.15 h. respectively. Difloxacin was distributed extravascularly with a volume of distribution (Vdss) 1.10 ± 0.035 l kg-1., and total body clearance (CLB) of 0.141+ 0.031 l kg-1 h-1. following intramusclar injection, peak serum concentration (Cmax) 2.59 ± 0.19 ug ml-1 attained after Tmax 3.05 ± 0.035 h. The absorption and elimination half lives (t0.5 (ab) and t0.5 (el)) were 0.95 ± 0.003 and 5.86 ± 0.33 h., respectively. The systemic bioavailablility (F) and the plasma protein binding were 87.95 and 23 %, respectively.

Keywords

• pharmacokinetics; bioavailability; difloxacin; camel