NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling

Heidi M. Britton; Adrian B. Levine; Yaoqing Shen; Karen Mungall; Jonathan Serrano; Matija Snuderl; Erin Pleasance; Steven J. M. Jones; Janessa Laskin; Marco A. Marra; Shahrad R. Rassekh; Rebecca Deyell; Stephen Yip; Sylvia Cheng; Chris Dunham

doi:10.1002/ccr3.3804

Clinical Case Reports (Mar 2021)

NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling

Heidi M. Britton,
Adrian B. Levine,
Yaoqing Shen,
Karen Mungall,
Jonathan Serrano,
Matija Snuderl,
Erin Pleasance,
Steven J. M. Jones,
Janessa Laskin,
Marco A. Marra,
Shahrad R. Rassekh,
Rebecca Deyell,
Stephen Yip,
Sylvia Cheng,
Chris Dunham

Affiliations

Heidi M. Britton: Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada
Adrian B. Levine: Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada
Yaoqing Shen: Canada's Michael Smith Genome Sciences CentreBritish Columbia Cancer Agency Vancouver Canada
Karen Mungall: Canada's Michael Smith Genome Sciences CentreBritish Columbia Cancer Agency Vancouver Canada
Jonathan Serrano: Department of Pathology New York University School of Medicine New York NY USA
Matija Snuderl: Department of Pathology New York University School of Medicine New York NY USA
Erin Pleasance: Canada's Michael Smith Genome Sciences CentreBritish Columbia Cancer Agency Vancouver Canada
Steven J. M. Jones: Canada's Michael Smith Genome Sciences CentreBritish Columbia Cancer Agency Vancouver Canada
Janessa Laskin: Canada's Michael Smith Genome Sciences CentreBritish Columbia Cancer Agency Vancouver Canada
Marco A. Marra: Canada's Michael Smith Genome Sciences CentreBritish Columbia Cancer Agency Vancouver Canada
Shahrad R. Rassekh: Division of Pediatric Hematology/Oncology British Columbia Children's Hospital and the University of British Columbia Vancouver BC Canada
Rebecca Deyell: Division of Pediatric Hematology/Oncology British Columbia Children's Hospital and the University of British Columbia Vancouver BC Canada
Stephen Yip: Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada
Sylvia Cheng: Division of Pediatric Hematology/Oncology British Columbia Children's Hospital and the University of British Columbia Vancouver BC Canada
Chris Dunham: Division of Anatomic Pathology Children's and Women's Health Centre of British Columbia Vancouver BC Canada

DOI: https://doi.org/10.1002/ccr3.3804
Journal volume & issue: Vol. 9, no. 3
pp. 1472 – 1477

Abstract

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Abstract This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.

Published in Clinical Case Reports

ISSN: 2050-0904 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2050-0904

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