Transcription factor competition regulates lysosomal biogenesis and autophagy

Abstract

“In the field of observation, chance favours only the prepared mind” (Louis Pasteur). This motto seems to have guided our unexpected results published recently in Nature Communications, where we describe an epigenetic rheostat that regulates expression of the constituents of the lysosomal and autophagic systems.

Keywords

• lysosome and autophagy gene transcription
• intermittent drainage
• epigenetic regulation
• acetylation
• myc
• mit/tfe