MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Xinyue Chen; Daniel B. Burkhardt; Amaleah A. Hartman; Xiao Hu; Anna E. Eastman; Chao Sun; Xujun Wang; Mei Zhong; Smita Krishnaswamy; Shangqin Guo

doi:10.1038/s41467-019-13666-5

Nature Communications (Dec 2019)

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Xinyue Chen,
Daniel B. Burkhardt,
Amaleah A. Hartman,
Xiao Hu,
Anna E. Eastman,
Chao Sun,
Xujun Wang,
Mei Zhong,
Smita Krishnaswamy,
Shangqin Guo

Affiliations

Xinyue Chen: Department of Cell Biology, Yale University
Daniel B. Burkhardt: Department of Genetics, Yale University
Amaleah A. Hartman: Department of Cell Biology, Yale University
Xiao Hu: Department of Cell Biology, Yale University
Anna E. Eastman: Department of Cell Biology, Yale University
Chao Sun: Department of Cell Biology, Yale University
Xujun Wang: SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University
Mei Zhong: Department of Cell Biology, Yale University
Smita Krishnaswamy: Department of Genetics, Yale University
Shangqin Guo: Department of Cell Biology, Yale University

DOI: https://doi.org/10.1038/s41467-019-13666-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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