TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

Gil Ju Seo; Charlotte Kim; Woo-Jin Shin; Ella H. Sklan; Hyungjin Eoh; Jae U. Jung

doi:10.1038/s41467-018-02936-3

Nature Communications (Feb 2018)

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

Gil Ju Seo,
Charlotte Kim,
Woo-Jin Shin,
Ella H. Sklan,
Hyungjin Eoh,
Jae U. Jung

Affiliations

Gil Ju Seo: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Charlotte Kim: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Woo-Jin Shin: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Ella H. Sklan: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Hyungjin Eoh: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Jae U. Jung: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/s41467-018-02936-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

The protein cGAS responds to the presence of cytosolic DNA by producing the second messenger cGAMP, which triggers antiviral interferon responses. Here, Seo et al. show that ubiquitination by the E3 ligase TRIM56 enhances cGAS activity and is important for the immune response against DNA viruses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal