Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity

Ruby C.Y. Lin; Sheau-Fang Ng; Margaret J. Morris

doi:10.1016/j.gdata.2014.09.013

Genomics Data (Dec 2014)

Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity

Ruby C.Y. Lin,
Sheau-Fang Ng,
Margaret J. Morris

Affiliations

Ruby C.Y. Lin: Asbestos Diseases Research Institute, NSW, 2139 Sydney, Australia
Sheau-Fang Ng: Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
Margaret J. Morris: Department of Pharmacology, School of Medical Sciences, University New South Wales, NSW 2052, Australia

DOI: https://doi.org/10.1016/j.gdata.2014.09.013
Journal volume & issue: Vol. 2, no. C
pp. 351 – 353

Abstract

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Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963–966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830–1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.

Published in Genomics Data

ISSN: 2213-5960 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Biology (General): Genetics
Website: http://www.journals.elsevier.com/genomics-data/

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