Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia

Hidehiko Maruyama; Katsuhiko Tada; Takuzo Fujiwara; Kosuke Ota; Misao Kageyama

doi:10.1055/s-0032-1329683

American Journal of Perinatology Reports (May 2013)

Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia

Hidehiko Maruyama,
Katsuhiko Tada,
Takuzo Fujiwara,
Kosuke Ota,
Misao Kageyama

Affiliations

Hidehiko Maruyama: Department of Neonatology, National Hospital Organization, Okayama Medical Center, Okayama, Japan
Katsuhiko Tada: Department of Obstetrics and Gynecology, National Hospital Organization, Okayama Medical Center, Okayama, Japan
Takuzo Fujiwara: Department of Surgery, National Hospital Organization, Okayama Medical Center, Okayama, Japan
Kosuke Ota: Department of Nephrology, National Hospital Organization, Okayama Medical Center, Okayama, Japan
Misao Kageyama: Department of Neonatology, National Hospital Organization, Okayama Medical Center, Okayama, Japan

DOI: https://doi.org/10.1055/s-0032-1329683
Journal volume & issue: Vol. 03, no. 01
pp. 025 – 028

Abstract

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Abstract An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 108 red blood cells, respectively. Maternal 6TGN levels could be useful in predicting neonatal pancytopenia.

Published in American Journal of Perinatology Reports

ISSN: 2157-6998 (Print); 2157-7005 (Online)
Publisher: Thieme Medical Publishers, Inc.
Country of publisher: United States
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://doi.org/10.1055/s-00000169

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Abstract

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