Modulation of Hoogsteen dynamics on DNA recognition

Yu Xu; James McSally; Ioan Andricioaei; Hashim M. Al-Hashimi

doi:10.1038/s41467-018-03516-1

Nature Communications (Apr 2018)

Modulation of Hoogsteen dynamics on DNA recognition

Yu Xu,
James McSally,
Ioan Andricioaei,
Hashim M. Al-Hashimi

Affiliations

Yu Xu: Department of Chemistry, Duke University
James McSally: Department of Chemistry, University of California Irvine
Ioan Andricioaei: Department of Chemistry, University of California Irvine
Hashim M. Al-Hashimi: Department of Chemistry, Duke University

DOI: https://doi.org/10.1038/s41467-018-03516-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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DNA is found in a dynamic equilibrium between standard Watson-Crick (WC) base pairs and non-standard Hoogsteen (HG) base pairs. Here the authors describe the influence of echinomycin and actinomycin D ligands binding on the HG-WC base pair dynamics in DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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