Nature Communications (Feb 2021)
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery
- Micah T. McClain,
- Florica J. Constantine,
- Ricardo Henao,
- Yiling Liu,
- Ephraim L. Tsalik,
- Thomas W. Burke,
- Julie M. Steinbrink,
- Elizabeth Petzold,
- Bradly P. Nicholson,
- Robert Rolfe,
- Bryan D. Kraft,
- Matthew S. Kelly,
- Daniel R. Saban,
- Chen Yu,
- Xiling Shen,
- Emily M. Ko,
- Gregory D. Sempowski,
- Thomas N. Denny,
- Geoffrey S. Ginsburg,
- Christopher W. Woods
Affiliations
- Micah T. McClain
- Durham Veterans Affairs Medical Center
- Florica J. Constantine
- Center for Applied Genomics and Precision Medicine, Duke University
- Ricardo Henao
- Center for Applied Genomics and Precision Medicine, Duke University
- Yiling Liu
- Center for Applied Genomics and Precision Medicine, Duke University
- Ephraim L. Tsalik
- Durham Veterans Affairs Medical Center
- Thomas W. Burke
- Center for Applied Genomics and Precision Medicine, Duke University
- Julie M. Steinbrink
- Center for Applied Genomics and Precision Medicine, Duke University
- Elizabeth Petzold
- Center for Applied Genomics and Precision Medicine, Duke University
- Bradly P. Nicholson
- Institute for Medical Research
- Robert Rolfe
- Division of Infectious Diseases, Duke University Medical Center
- Bryan D. Kraft
- Durham Veterans Affairs Medical Center
- Matthew S. Kelly
- Duke University Medical Center
- Daniel R. Saban
- Department of Opthalmology, Duke University School of Medicine
- Chen Yu
- Department of Opthalmology, Duke University School of Medicine
- Xiling Shen
- Center for Genomics and Computational Biology, Duke University
- Emily M. Ko
- Center for Applied Genomics and Precision Medicine, Duke University
- Gregory D. Sempowski
- Duke Human Vaccine Institute
- Thomas N. Denny
- Duke Human Vaccine Institute
- Geoffrey S. Ginsburg
- Center for Applied Genomics and Precision Medicine, Duke University
- Christopher W. Woods
- Durham Veterans Affairs Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-21289-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
The systemic immune features that distinguish COVID-19 from common infections remain incompletely elucidated. Here McClain et al. compare RNA sequencing in peripheral blood between subjects with SARS-CoV-2 and other respiratory infections and demonstrate dysregulated immune responses in COVID-19 with both heterogeneous and conserved components.
