Bioengineering (Feb 2017)

Antioxidant Activity of SOD and Catalase Conjugated with Nanocrystalline Ceria

  • Dmitry Gil,
  • Jeannette Rodriguez,
  • Brendan Ward,
  • Alexey Vertegel,
  • Vladimir Ivanov,
  • Vladimir Reukov

DOI
https://doi.org/10.3390/bioengineering4010018
Journal volume & issue
Vol. 4, no. 1
p. 18

Abstract

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Interactions of nanoparticles with biological matter—both somatically and in nature—draw scientists’ attention. Nanoparticulate systems are believed to be our saviors, acting as versatile drug delivery vehicles. However, they can also cause life-threatening bodily damage. One of the most important properties of nanocrystalline cerium dioxide is its antioxidant activity, which decreases the abundance of reactive oxygen species during inflammation. In this paper, we report on synergistic effects of inorganic cerium oxide (IV) nanoparticles conjugated with the antioxidative enzymes superoxide dismutase and catalase on scavenging oxygen and nitrogen radicals.

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