Nature Communications (Oct 2016)
Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
- R. A. Pearson,
- A. Gonzalez-Cordero,
- E. L. West,
- J. R. Ribeiro,
- N. Aghaizu,
- D. Goh,
- R. D. Sampson,
- A. Georgiadis,
- P. V. Waldron,
- Y. Duran,
- A. Naeem,
- M. Kloc,
- E. Cristante,
- K. Kruczek,
- K. Warre-Cornish,
- J. C. Sowden,
- A. J. Smith,
- R. R. Ali
Affiliations
- R. A. Pearson
- Department of Genetics, University College London Institute of Ophthalmology
- A. Gonzalez-Cordero
- Department of Genetics, University College London Institute of Ophthalmology
- E. L. West
- Department of Genetics, University College London Institute of Ophthalmology
- J. R. Ribeiro
- Department of Genetics, University College London Institute of Ophthalmology
- N. Aghaizu
- Department of Genetics, University College London Institute of Ophthalmology
- D. Goh
- Department of Genetics, University College London Institute of Ophthalmology
- R. D. Sampson
- Department of Genetics, University College London Institute of Ophthalmology
- A. Georgiadis
- Department of Genetics, University College London Institute of Ophthalmology
- P. V. Waldron
- Department of Genetics, University College London Institute of Ophthalmology
- Y. Duran
- Department of Genetics, University College London Institute of Ophthalmology
- A. Naeem
- Department of Genetics, University College London Institute of Ophthalmology
- M. Kloc
- Department of Genetics, University College London Institute of Ophthalmology
- E. Cristante
- Department of Genetics, University College London Institute of Ophthalmology
- K. Kruczek
- Department of Genetics, University College London Institute of Ophthalmology
- K. Warre-Cornish
- Department of Genetics, University College London Institute of Ophthalmology
- J. C. Sowden
- Stem Cells and Regenerative Medicine Section
- A. J. Smith
- Department of Genetics, University College London Institute of Ophthalmology
- R. R. Ali
- Department of Genetics, University College London Institute of Ophthalmology
- DOI
- https://doi.org/10.1038/ncomms13029
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic material between donor and host cells in vivo.
