Nature Communications (Sep 2016)
Determining crystal structures through crowdsourcing and coursework
- Scott Horowitz,
- Brian Koepnick,
- Raoul Martin,
- Agnes Tymieniecki,
- Amanda A. Winburn,
- Seth Cooper,
- Jeff Flatten,
- David S. Rogawski,
- Nicole M. Koropatkin,
- Tsinatkeab T. Hailu,
- Neha Jain,
- Philipp Koldewey,
- Logan S. Ahlstrom,
- Matthew R. Chapman,
- Andrew P. Sikkema,
- Meredith A. Skiba,
- Finn P. Maloney,
- Felix R. M. Beinlich,
- Foldit Players,
- University of Michigan students,
- Zoran Popović,
- David Baker,
- Firas Khatib,
- James C. A. Bardwell
Affiliations
- Scott Horowitz
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Brian Koepnick
- Department of Biochemistry, University of Washington
- Raoul Martin
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Agnes Tymieniecki
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Amanda A. Winburn
- Department of Informatics, Center for Complex Networks and Systems Research, Indiana University
- Seth Cooper
- Northeastern University, College of Computer and Information Science
- Jeff Flatten
- Department of Computer Science and Engineering, Center for Game Science, University of Washington
- David S. Rogawski
- Department of Pathology, University of Michigan
- Nicole M. Koropatkin
- Department of Microbiology and Immunology, University of Michigan
- Tsinatkeab T. Hailu
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Neha Jain
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Philipp Koldewey
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Logan S. Ahlstrom
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Matthew R. Chapman
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Andrew P. Sikkema
- Department of Biological Chemistry and Life Sciences Institute, University of Michigan
- Meredith A. Skiba
- Department of Biological Chemistry and Life Sciences Institute, University of Michigan
- Finn P. Maloney
- Chemical Biology Doctoral Program, University of Michigan
- Felix R. M. Beinlich
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Foldit Players
- University of Michigan students
- Zoran Popović
- Department of Computer Science and Engineering, Center for Game Science, University of Washington
- David Baker
- Department of Biochemistry, University of Washington
- Firas Khatib
- Department of Computer and Information Science, University of Massachusetts Dartmouth
- James C. A. Bardwell
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- DOI
- https://doi.org/10.1038/ncomms12549
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure, and find that crowdsourcing model-building works.
