Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors

Mingzhi Zhu; Pei Wang; Biaoqi Chen; Linrong Shi; Ruimin Long; Shibin Wang; Yuangang Liu

Materials & Design (Jan 2024)

Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors

Mingzhi Zhu,
Pei Wang,
Biaoqi Chen,
Linrong Shi,
Ruimin Long,
Shibin Wang,
Yuangang Liu

Affiliations

Mingzhi Zhu: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, China
Pei Wang: School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China; College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China; Corresponding authors at: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China (M. Zhu and Y. Liu). School of Stomatology, Nanchang University, Nanchang 330006, China (P. Wang).
Biaoqi Chen: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, China
Linrong Shi: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
Ruimin Long: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
Shibin Wang: Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, China; College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China
Yuangang Liu: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen 361021, China; Corresponding authors at: College of Chemical Engineering, Huaqiao University, Xiamen 361021, China (M. Zhu and Y. Liu). School of Stomatology, Nanchang University, Nanchang 330006, China (P. Wang).

Journal volume & issue: Vol. 237
p. 112618

Abstract

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Such is the hypoxia in solid tumor that Ⅱ-type photodynamic therapy (PDT) has not yet achieved significantly satisfactory consequences. Despite the rapid advancement in nanotechnology-based PDT for alleviating the hypoxic tumor microenvironment, several challenges persist. These include inefficient passive oxygen-supply mechanisms, low stability of oxygen-delivery nanosystems, and the complexity of their modification processes. To address these issues, we developed integrative nanoformulations (HHI NPs) by sequentially inserting biomacromolecule hemoglobin (Hb) and IR783 (photosensitizer) into hollow mesoporous Prussian blue (HPB NPs) through a straightforward and gentle diffusion method. Intriguingly, the resulting hybrid nanocomposites based on hollow mesoporous structure provided stability of biomacromolecule Hb, ensuring active and efficient oxygen delivery. In these nanosystems, HHI NPs equipped with high oxygen-carrying Hb efficiently generated reactive oxygen species over HepG2 cells cultured in hypoxic condition under NIR irradiation. Additionally, HPB NPs served not only as nanocarriers but also as photothermal agents exhibiting excellent photothermal conversion effects. which were beneficial for photothermal therapy (PTT) of cancer. HHI NPs co-loaded with Hb and IR783 not only actively relieved the hypoxic TME through the stable protection of the hollow structure from HPB NPs, but also achieve the significant synergistic therapy by combining PDT and PTT for tumor treatment.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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