Бюллетень сибирской медицины (May 2019)

Genetic factors influencing HIV entry into target cells

  • R. M. Khaitov,
  • L. P. Alexeev,
  • I. A. Kofiadi,
  • G. O. Gudima

DOI
https://doi.org/10.20538/1682-0363-2019-1-131-141
Journal volume & issue
Vol. 18, no. 1
pp. 131 – 141

Abstract

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Succeptibility to HIV and the dynamics of HIV infection progression to AIDS are dependent on unique individual factors. Revealing genetic features of natural resistance to HIV infection is of great importance for the development of effective strategies for disease control. This review presents an analysis of host gene alleles coding receptors and their ligands participating in viral entrance to target cell. These allelic variants and their combinations can have a significant influence on the individual resistance/sensitivity to HIV infection and may be associated with the HIV infection progression to AIDS.

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