The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer

Abstract

Abstract Background One of the well-differentiated types of thyroid cancer is papillary thyroid cancer (PTC), often developed by genetic mutations and radiation. Methods In this study, the public NCBI-GEO database was systematically searched. The eligible datasets were the targets for biomarker discovery associated with PI3K signaling pathway. Results Only two datasets were suitable and passed the inclusion criteria. The meta-analysis outcomes revealed eleven upregulation and thirteen downregulation genes differentially expressed between PTC and healthy tissues. Moreover, the outcomes for survival and disease-free rates for each gene were illustrated. Conclusions The present research suggests a panel signature of 24 gene biomarkers in diagnosing the PTC.

Keywords

• Papillary thyroid cancer
• Meta-analysis
• GEO datasets
• Signaling pathway
• Biomarker