Nature Communications (Oct 2019)
N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
- Ri-Xin Chen,
- Xin Chen,
- Liang-Ping Xia,
- Jia-Xing Zhang,
- Zhi-Zhong Pan,
- Xiao-Dan Ma,
- Kai Han,
- Jie-Wei Chen,
- Jean-Gabrie Judde,
- Olivier Deas,
- Feng Wang,
- Ning-Fang Ma,
- Xinyuan Guan,
- Jing-Ping Yun,
- Feng-Wei Wang,
- Rui-Hua Xu,
- Dan Xie
Affiliations
- Ri-Xin Chen
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Xin Chen
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Liang-Ping Xia
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Jia-Xing Zhang
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Zhi-Zhong Pan
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Xiao-Dan Ma
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Kai Han
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Jie-Wei Chen
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Jean-Gabrie Judde
- XenTech SAS
- Olivier Deas
- XenTech SAS
- Feng Wang
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Ning-Fang Ma
- Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University
- Xinyuan Guan
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Jing-Ping Yun
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Feng-Wei Wang
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Rui-Hua Xu
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Dan Xie
- State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-019-12651-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.
