Double-stranded RNA virus outer shell assembly by bona fide domain-swapping

Zhaoyang Sun; Kamel El Omari; Xiaoyu Sun; Serban L. Ilca; Abhay Kotecha; David I. Stuart; Minna M. Poranen; Juha T. Huiskonen

doi:10.1038/ncomms14814

Nature Communications (Mar 2017)

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping

Zhaoyang Sun,
Kamel El Omari,
Xiaoyu Sun,
Serban L. Ilca,
Abhay Kotecha,
David I. Stuart,
Minna M. Poranen,
Juha T. Huiskonen

Affiliations

Zhaoyang Sun: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
Kamel El Omari: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
Xiaoyu Sun: Department of Biosciences, University of Helsinki
Serban L. Ilca: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
Abhay Kotecha: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
David I. Stuart: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
Minna M. Poranen: Department of Biosciences, University of Helsinki
Juha T. Huiskonen: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford

DOI: https://doi.org/10.1038/ncomms14814
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Double-shelled bacteriophage φ6 is a well-studied model system used to understand assembly of dsRNA viruses. Here the authors report a near-atomic resolution cryo-EM structure of φ6 and propose a model for the structural transitions occurring in the outer shell during genome packaging.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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