Nature Communications (Aug 2022)

Water-organizing motif continuity is critical for potent ice nucleation protein activity

  • Jordan Forbes,
  • Akalabya Bissoyi,
  • Lukas Eickhoff,
  • Naama Reicher,
  • Thomas Hansen,
  • Christopher G. Bon,
  • Virginia K. Walker,
  • Thomas Koop,
  • Yinon Rudich,
  • Ido Braslavsky,
  • Peter L. Davies

DOI
https://doi.org/10.1038/s41467-022-32469-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Ice nucleation proteins have the same tandemly arrayed water-organizing motifs seen in some antifreeze proteins, but on a larger scale. The authors show that mutation, interruption, and truncation of these arrays reduce ice nucleation activity indicating that the two protein types share a common mechanism.