Nature Communications (Mar 2019)
Assessing the causal association of glycine with risk of cardio-metabolic diseases
- Laura B. L. Wittemans,
- Luca A. Lotta,
- Clare Oliver-Williams,
- Isobel D. Stewart,
- Praveen Surendran,
- Savita Karthikeyan,
- Felix R. Day,
- Albert Koulman,
- Fumiaki Imamura,
- Lingyao Zeng,
- Jeanette Erdmann,
- Heribert Schunkert,
- Kay-Tee Khaw,
- Julian L. Griffin,
- Nita G. Forouhi,
- Robert A. Scott,
- Angela M. Wood,
- Stephen Burgess,
- Joanna M. M. Howson,
- John Danesh,
- Nicholas J. Wareham,
- Adam S. Butterworth,
- Claudia Langenberg
Affiliations
- Laura B. L. Wittemans
- MRC Epidemiology Unit, University of Cambridge
- Luca A. Lotta
- MRC Epidemiology Unit, University of Cambridge
- Clare Oliver-Williams
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Isobel D. Stewart
- MRC Epidemiology Unit, University of Cambridge
- Praveen Surendran
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Savita Karthikeyan
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Felix R. Day
- MRC Epidemiology Unit, University of Cambridge
- Albert Koulman
- MRC Epidemiology Unit, University of Cambridge
- Fumiaki Imamura
- MRC Epidemiology Unit, University of Cambridge
- Lingyao Zeng
- Deutsches Herzzentrum München, Technische Universität München
- Jeanette Erdmann
- Institute for Cardiogenetics, University of Lübeck
- Heribert Schunkert
- Deutsches Herzzentrum München, Technische Universität München
- Kay-Tee Khaw
- Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge
- Julian L. Griffin
- Biochemistry Department, University of Cambridge
- Nita G. Forouhi
- MRC Epidemiology Unit, University of Cambridge
- Robert A. Scott
- MRC Epidemiology Unit, University of Cambridge
- Angela M. Wood
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Stephen Burgess
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Joanna M. M. Howson
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- John Danesh
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge
- Adam S. Butterworth
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-019-08936-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a causal relationship with coronary heart disease using MR.
