SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression

Qing Nian; Jingwei Li; ZhongYu Han; Qi Liang; Maoyu Liu; Chan Yang; Fernando Rodrigues-Lima; Tao Jiang; Liyun Zhao; Jinhao Zeng; Chi Liu; Jianyou Shi

Biomedicine & Pharmacotherapy (Sep 2022)

SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression

Qing Nian,
Jingwei Li,
ZhongYu Han,
Qi Liang,
Maoyu Liu,
Chan Yang,
Fernando Rodrigues-Lima,
Tao Jiang,
Liyun Zhao,
Jinhao Zeng,
Chi Liu,
Jianyou Shi

Affiliations

Qing Nian: Transfusion Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China
Jingwei Li: Transfusion Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China
ZhongYu Han: School of Medical and Life Sciences, Reproductive and Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
Qi Liang: College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 611756, China
Maoyu Liu: Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China
Chan Yang: Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China
Fernando Rodrigues-Lima: Unité de Biologie Fonctionnelle et Adaptative, Université de Paris, Paris 75013, France
Tao Jiang: Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China
Liyun Zhao: Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China
Jinhao Zeng: Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China; Corresponding authors.
Chi Liu: Renal Department and Nephrology Institute, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Clinical Research Center for Kidney Diseases, Chengdu 610072, China; Corresponding authors.
Jianyou Shi: Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China; Corresponding authors.

Journal volume & issue: Vol. 153
p. 113519

Abstract

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Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or BM-40, is a matricellular protein involved in several biological processes including cell adhesion, growth factor availability, extracellular matrix remodeling and immune-regulation. SPARC has also been associated with a variety of diseases including diabetes, colon cancer, and leukemia. The expression of SPARC in different diseases exhibits some degree of ambiguity, especially in hemopathies. Herein, we review the current expression and effects of SPARC in various hematologic disorders with respect to nanoparticle albumin bound innovative therapies and related diagnostic research, providing a clinical perspective on the use of NAB technology in the frontier treatment of hematologic diseases.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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