Treatment of severe radiation proctitis with high dosage of vitamin C in combination with cyclooxygenase-2 inhibitor

Han Wu; Miaomiao Liu; Huangang Jiang; Hui Xu; Jin Peng; Jing Dai; Fuxiang Zhou

Radiation Medicine and Protection (Jun 2024)

Treatment of severe radiation proctitis with high dosage of vitamin C in combination with cyclooxygenase-2 inhibitor

Han Wu,
Miaomiao Liu,
Huangang Jiang,
Hui Xu,
Jin Peng,
Jing Dai,
Fuxiang Zhou

Affiliations

Han Wu: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430007, China
Miaomiao Liu: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430007, China
Huangang Jiang: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430007, China
Hui Xu: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430007, China
Jin Peng: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430007, China
Jing Dai: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430007, China; Corresponding author. Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, 430007, China.
Fuxiang Zhou: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan 430007, China; Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430007, China; Corresponding author. Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, 430007, China.

Journal volume & issue: Vol. 5, no. 2
pp. 113 – 117

Abstract

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Objective: To explore the new treatment strategies for radiation proctitis, which is the most common complication of pelvic tumor malignancies. Methods: Four cases of patients with severe radiation proctitis were treated with high-dosage vitamin C (VC, 12–24 g/d, iv) combined with cyclooxygenase-2 (cyclooxygenase-2, COX-2) inhibitors. Results: For these four cases, the diarrhea, hematochezia, tenesmus, pain, and other symptoms were significantly improved. The edema of the rectal wall is also significantly improved in the imaging review. Conclusion: The high-dosage VC combined with the treatment of severe radiation proctitis is safe and effective.

Published in Radiation Medicine and Protection

ISSN: 2666-5557 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiation-medicine-and-protection

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