Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides

Zhangpei Chen; Qinglong Shi; Gongshu Wang; Siwen Chen; Jianshe Hu

doi:10.3390/molecules23061240

Molecules (May 2018)

Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides

Zhangpei Chen,
Qinglong Shi,
Gongshu Wang,
Siwen Chen,
Jianshe Hu

Affiliations

Zhangpei Chen: Center for Molecular Science and Engineering, College of Sciences, Northeastern University, Shenyang 110819, China
Qinglong Shi: Center for Molecular Science and Engineering, College of Sciences, Northeastern University, Shenyang 110819, China
Gongshu Wang: Center for Molecular Science and Engineering, College of Sciences, Northeastern University, Shenyang 110819, China
Siwen Chen: Center for Molecular Science and Engineering, College of Sciences, Northeastern University, Shenyang 110819, China
Jianshe Hu: Center for Molecular Science and Engineering, College of Sciences, Northeastern University, Shenyang 110819, China

DOI: https://doi.org/10.3390/molecules23061240
Journal volume & issue: Vol. 23, no. 6
p. 1240

Abstract

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An efficient and practical approach towards bifunctional phosphorus phenols has been developed through a reaction of diphenylphosphine oxide and the o-quinone methides in situ generated from 2-tosylalkyl phenols under basic conditions. This protocol features simple experimental procedures under mild conditions and is easily scaled up. With this method, a variety of diarylmethyl phosphine oxides can be produced with up to 92% yield.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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