Nature Communications (Nov 2019)
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
- Jiancheng Wang,
- Qiying Lu,
- Jianye Cai,
- Yi Wang,
- Xiaofan Lai,
- Yuan Qiu,
- Yinong Huang,
- Qiong Ke,
- Yanan Zhang,
- Yuanjun Guan,
- Haoxiang Wu,
- Yuanyuan Wang,
- Xin Liu,
- Yue Shi,
- Kang Zhang,
- Maosheng Wang,
- Andy Peng Xiang
Affiliations
- Jiancheng Wang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University
- Qiying Lu
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University
- Jianye Cai
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Yi Wang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University
- Xiaofan Lai
- Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University
- Yuan Qiu
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University
- Yinong Huang
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Qiong Ke
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University
- Yanan Zhang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University
- Yuanjun Guan
- Core Facility of Center, Zhongshan School of Medicine, Sun Yat-Sen University
- Haoxiang Wu
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Yuanyuan Wang
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Xin Liu
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Yue Shi
- Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University
- Kang Zhang
- Faculty of Medicine, Macau University of Science and Technology
- Maosheng Wang
- The Cardiovascular Center, Gaozhou People’s Hospital
- Andy Peng Xiang
- Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University
- DOI
- https://doi.org/10.1038/s41467-019-12925-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in NSCLC.
