Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes

• Jian-Jung Pan,
• Jose O. Solbiati,
• Gurusankar Ramamoorthy,
• Brandan S. Hillerich,
• Ronald D. Seidel,
• John E. Cronan,
• Steven C. Almo,
• C. Dale Poulter

Affiliations

Jian-Jung Pan

Department of Chemistry, University of Utah, Salt Lake City, Utah, United States

Jose O. Solbiati

Institute for Genomic Biology, University of Illinois at Urbana−Champaign, Urbana, Illinois, United States

Gurusankar Ramamoorthy

Department of Chemistry, University of Utah, Salt Lake City, Utah, United States

Brandan S. Hillerich

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States

Ronald D. Seidel

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States

John E. Cronan

Department of Microbiology, University of Illinois at Urbana−Champaign, Urbana, Illinois, United States

Steven C. Almo

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States

C. Dale Poulter

Department of Chemistry, University of Utah, Salt Lake City, Utah, United States