Access to Artemisinin–Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity against Multi-Drug-Resistant Malaria Parasites

• Lars Herrmann,
• Maria Leidenberger,
• Helenita C. Quadros,
• Benedikt W. Grau,
• Frank Hampel,
• Oliver Friedrich,
• Diogo R. M. Moreira,
• Barbara Kappes,
• Svetlana B. Tsogoeva

Affiliations

Lars Herrmann

Department of Chemistry and Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

Maria Leidenberger

Institute of Medical Biotechnology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

Helenita C. Quadros

Fiocruz, Instituto Gonçalo Moniz, Salvador, Bahia, Brazil

Benedikt W. Grau

Department of Chemistry and Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

Frank Hampel

Department of Chemistry and Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

Oliver Friedrich

Institute of Medical Biotechnology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

Diogo R. M. Moreira

Fiocruz, Instituto Gonçalo Moniz, Salvador, Bahia, Brazil

Barbara Kappes

Institute of Medical Biotechnology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

Svetlana B. Tsogoeva

Department of Chemistry and Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany